Frustrated radical pairs (FRP) are generated from frustrated Lewis pairs by means of single-electron transfer from the Lewis acid (oxidant) to the Lewis base (reductant). Owing to steric encumbrance and/or weak bonding association, these radicals do not react with each other to form a close-shelled adduct. We harness the unquenched orthogonal reactivity of frustrated radicals to activate strong chemical bonds such as C–H bonds.

Aminoxyls are a class of persistent organic radicals that exhibit unique single- and two-electron redox activities. We explore aminoxyl radicals as catalysts in a variety of chemical and electrochemical transformations with a focus on catalyst design that allows for precise control over regio- and stereoselectivity.

We employ the complexes of first-row transition metals as catalysts to impart chemo- and stereoselective control of radical-mediated reactions. Specific examples include Ti-catalyzed cycloaddition and isomerization, Co-catalyzed hydrogen-atom transfer, Mn-catalyzed alkene difucntionalization, and Cu-catalyzed enantioselective radical reactions.